Re: [新聞] 全球首例官方認證 俄國衛生部指武漢肺炎

※ 引述《girl10319 (凱莉)》之銘言： :《信傳媒》持續報導病毒非自然形成，例如最早引證在1月27日的華人媒體《路德社》指 :是舟山蝙蝠病毒合成，到印度學者發表被植入愛滋病毒一部分基因，到最近美國生物基? :析專家里昂斯維勒（James Lyons-Weiler）日前受訪時表示，新型冠狀病毒有使用「P-S : tle SN Vector」的人造技術，基因組序列裡被插入奇怪的元素，不可能存在於任何地方 雖然中共政權很糟糕很腦殘, 但是如果我們用一樣腦殘的方式去攻擊它們, 那只不過是讓雙方變成一樣腦殘. 這樣不只不能打擊中共政權, 反而讓己方的可信度徹底瓦解. Google "james lyons-weiler coronavirus pshuttle sn vector" https://reurl.cc/W4p167 2019 novel coronavirus (2019-nCoV) does not contain “pShuttle-SN” sequence; no evidence that virus is man-made https://reurl.cc/Obx4lg Baseless Conspiracy Theories Claim New Coronavirus Was Bioengineered 沒有生物工程的跡象 至於該病毒是經過生物工程改造的一般概念，沒有證據是正確的。相反，正如我們解釋 之前，病毒的證據點的所有行從動物的到來。Sheahan說，這與科學家在過去20年中了解 到的冠狀病毒生態學是一致的，包括SARS和MERS-並且符合該病毒與蝙蝠病毒共享其基因 組96％的事實。 他說：“遺傳數據表明這種病毒來自蝙蝠庫，而不是實驗室。” 不僅病毒中沒有HIV“插入物”，而且通過查看病毒的基因組，科學家還發現了零篡改 跡象。 弗雷德·哈欽森（Fred Hutchinson）的計算生物學家貝德福德（Bedford）在推特上指出 ，該病毒與其最近的祖先的遺傳差異與“預期在自然進化過程中產生的差異一致”。 他解釋說，一種工程病毒可能具有“畸變的”氨基酸與核苷酸比率，並且其變化集中在“ 基因子集”上。換句話說，當工程發生時，通常是給病毒帶來了有意義的變化-但是在 2019-nCoV基因組中沒有證據表明這一點。 通常，科學家以有針對性的方式改變核苷酸，從而在其編碼的氨基酸中產生改變。由於 氨基酸是蛋白質的組成部分，因此這就是改變病毒產生的蛋白質的方法。 但是正如貝德福德所說，在所有的核苷酸變化中，只有很少的變化（約14％）會改變相應 的氨基酸，或者改變您對自然進化的病毒的期望。這個比率也與發現與2019-nCoV最相似 的蝙蝠病毒的比率相匹配。 此外，當比較確實存在的氨基酸變化時，2019-nCoV和蝙蝠病毒中各個基因的變化數量 非常相似。同樣，如果已經對病毒進行了工程改造，人們可能會期望許多變化會聚集在 一個或兩個基因中，但事實並非如此。所有這些都與新病毒已經脫離實驗室的想法背道 而馳一個或兩個基因中，但事實並非如此。所有這些都與新病毒已經脫離實驗室的想法 背道而馳。 Sources McDonald, Jessica. “Q&A on the Wuhan Coronavirus.” FactCheck.org. 30 Jan 2020. McDonald, Jessica. “Social Media Posts Spread Bogus Coronavirus Conspiracy Theory.” FactCheck.org. 24 Jan 2020. Novel coronavirus (2019-nCoV). World Health Organization. Accessed 7 Feb 2020. Pradhan, Prashant et. al. Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag. bioRxiv. 31 Jan 2020. Konermann, Silvana (@SKonermann). “Just checked their results. The similarity is spurious. Out of 4 inserts they identify between NCov and SARS, 2 are found in bat coronavirus. Of the remaining two, only one is most similar to HIV, and is so short (6 AA) that the similarity is not higher than chance given database.” Twitter. 31 Jan 2020. Bedford, Trevor (@trvrb). “These short inserts do indeed exist in #nCoV2019 relative to its closest sequenced relative (BetaCoV/bat/Yunnan/RaTG13/2013, seen here https://nextstrain.org/groups/blab/sars-like-cov). However, a simple BLAST of such short sequences shows match to a huge variety of organisms. No reason to conclude HIV.” Twitter. 31 Jan 2020. Severe Acute Respiratory Syndrome (SARS). CDC. Accessed 7 Feb 2020. Bedford, Trevor (@trvrb). “Based on the content of my mentions, I feel like I need to further debunk crazy #nCoV2019 / HIV conspiracy preprint. This is a thread doing so. 1/9, and following thread.” Twitter. 1 Feb 2020. Andersen, Kristian. Associate Professor, Department of Integrative Structural and Computational Biology, The Scripps Research Institute. Email sent to FactCheck.org. 3 Feb 2020. “China testing HIV drug as treatment for new coronavirus, AbbVie says.” Reuters. 26 Jan 2020. Wongcha-um, Panu. “Cocktail of flu, HIV drugs appears to help fight coronavirus: Thai doctors.” Reuters. 2 Feb 2020. Sheahan, Timothy. Assistant Professor, Department of Epidemiology, the Gillings School of Global Public Health, University of North Carolina at Chapel Hill. Interview with FactCheck.org. 5 Feb 2020. Chu, C. et. al. “Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings.” Thorax. 59(3), 2004. Sheahan, Timothy P. et. al. “Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.” Nature Communications. 11, 2020. Arabi, Yaseen M. et. al. “Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial.” Trials. 19(81), 2018. Arabi, Yaseen M. et. al. “Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial.” Trials. 21(8), 2020. Zhou, Peng et. al. “A pneumonia outbreak associated with a new coronavirus of probable bat origin.” Nature, 2020. Bedford, Trevor (@trvrb). “I thought to examine signal of natural evolution in #nCoV2019 by looking at distribution of mutations in the lineage leading to nCoV and compare this distribution to mutations occurring in other SARS-like bat viruses 1/9, and following thread.” Twitter. 3 Feb 2020. -- -- ※ 發信站: 批踢踢實業坊(ptt.cc), 來自: 67.169.164.13 (美國) ※ 文章網址: https://www.ptt.cc/bbs/nCoV2019/M.1582261186.A.7AD.html